2022 Lexus RX 350 AWD Personalize Find a car: 6 cyl, 3.5 L, Automatic (S8) Compare: Fuel Economy; EPA MPG: Regular Gasoline Combined MPG: 22. combined. city/highway. MPG. City MPG: 19. city. Highway MPG: 26. highway. 4.5 gals/100 miles . Unofficial MPG Estimates Shared by Vehicle Owners : View Estimates How can I share my MPG? Vehicle.. Hybrid power takes a front seat, as three of the four power options are hybrid, with one being a plug-in hybrid model. FWD and AWD are options that make the RX a versatile beast with a pretty face.
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View detailed gas mileage data for the 2023 Lexus RX 350. Use our handy tool to get estimated annual fuel costs based on your driving habits.. The 2023 Lexus RX 350 comes with a Gasoline powertrain making 275 horsepower and 317 lb-ft of torque. Efficiency for the Lexus RX 350 is 11.2 L/100km in the city, 8.4 L/100km on the highway and 9..